
A young woman in India received arms from a darker-skinned male donor after losing both of her hands in a bus accident. Her transplanted hands’ skin has faded with time.
Shreya Siddanagowder, had her arms amputated below the elbow after an accident in 2016. According to The Indian Express, she underwent a 13-hour transplant operation in 2017 by a team of 20 doctors and 16 anesthesiologists.
Her new hands were donated by a 21-year-old guy who died in a bicycle accident. Physical treatment improved Siddanagowder’s motor control of her arms and hands over the next year and a half, and they gradually became slimmer than they were before the transplant. According to The Indian Express, there was another unexpected change: the skin on her new limbs, which had been darker since the donor had a darker complexion, became lighter in color, more nearly matching Siddanagowder’s skin tone.

Siddanagowder’s physicians believe her body generates less melanin than her donor’s, which could explain why her new arms are lighter (melanin is a pigment that lends skin its color). Dr. Uday Khopkar, head of dermatology at King Edward Memorial Hospital in Mumbai, told The Indian Express that more research is needed to determine the cause.
According to the Mayo Clinic, candidates for hand transplants go through months of evaluations and discussions. Experts examine the patient’s overall health, including blood tests, X-rays, and nerve function in amputated limbs. According to the Mayo Clinic, eligible applicants are placed on a waiting list and matched with hand donors based on variables such as skin color, hand size, and blood type.

Siddanagowder’s visit to the Manipal Institute of Technology’s transplant department in Karnataka, India, to register for a transplant coincided with a matching blood type hand donation. According to The Indian Express, her surgery was Asia’s first double hand transplant as well as the continent’s first intergender limb transplant.
“I am the first female in the world to have male hands,” Siddanagowder claimed in a video posted on Facebook by the MOHAN Foundation in June 2019, a charity nongovernmental organization that promotes pioneering research in transplantation and organ donation in India.
However, her hands “have feminine features now,” Siddanagowder added.
Slimmer and lighter
According to physiotherapist Ketaki Doke, who worked with Siddanagowder in her hometown of Pune, one explanation for her hands taking on a more “feminine” form could be the muscles adapting to their new host.

“The nerve starts sending messages — this is called reinnervation — and the muscles respond to the body’s needs,” Doke explained. “Her hand muscles may have begun to adapt to a feminine physique.”
Siddanagowder rolled up her left sleeve in the video to show where the transplanted forearm joined her arm, remarking that the forearm’s formerly darker tone had lightened since the transplant in 2017.
“Now it matches my own skin color,” she said.
According to Johns Hopkins Medicine in Baltimore, just about 100 people have had their hands transplanted worldwide. According to Dr. Subramania Iyer, head of plastic and reconstructive surgery at the Amrita Institute of Medical Sciences in Kerala, India, Siddanagowder’s doctors are monitoring the changes in her hands’ skin color and shape, and they plan to publish the details of her transplant and recovery in a case report.
Iyer told The Indian Express that further evidence is needed to figure out what is causing these changes in her transplanted hands.

Henrietta Lacks: Who Was She? Here's how HeLa cells became necessary for medical research
Henrietta Lacks was died in 1951. The tumor that killed her has been alive and growing to this day. The tumor is immortal and was used to progress the Polio vaccine and is the jumping point for most human cell research to this day. Scientists have grown some 20 tons of her cells.

The Science Behind Pigeons in Cancer Detection and What It Means for Medicine
In a groundbreaking study, researchers have discovered that pigeons can be trained to distinguish between cancerous and non-cancerous tissues in medical images with accuracy rivaling that of human experts. This surprising capability opens new avenues for understanding visual perception and has potential implications for improving diagnostic tools in medicine. Here is the fascinating science behind pigeons’ ability to spot cancer and what it signifies for the future of medical imaging.

Meteorite found in Sahara Desert older than the earth
This Sahara Desert Meteorite was discovered to be older than the earth itself. This Meteorite is estimated to be 4.6 billion years old, while earth is estimated to be 4.54 billion years old.

For the First Time in 60 Years, Scientists Discover a 'Lost' Echidna Species
An expedition team in Indonesia discovered the elusive, egg-laying animal (Echidna) named after David Attenborough, which had not been seen since 1961.

The Mystery of the Dancing Forest: Reasons behind the unusual wonders of forest
The Dancing Forest in Russia is noted for its unusually twisted pine trees. The trunks of these trees are contorted into spirals, rings, and other squiggly loops, but the reason for this malformation is still a mystery.

George Dantzig solved two famous “unsolved” problems in statistics mistakenly as assignment
In 1939, George Dantzig arrived late to his statistics class. On the board were two famous “unsolved” problems in statistics written as an example by his professor. Dantzig mistook the examples for homework assignments. He solved the “unsolved” problems and submitted the homework to his professor a few days later. His solutions earned him a doctorate.

The story of Lionel the Lion-Faced Man, Stephan Bibrowski
Stephen Bibrowski, also known as Lionel the Lion-faced Man, was a well-known sideshow entertainer. His entire body was covered in long hair, giving him the appearance of a lion; this was most likely due to a rare condition known as hypertrichosis. Lionel traveled to the United States in 1901 and began performing with the Barnum and Bailey Circus.

Stephen Hawking’s Warning: Humanity Has Less Than 200 Years to Escape Earth’s Limits
Stephen hawking says humanity won't survive without leaving earth. In fact, human beings may have less than 200 years to figure out how to escape our planet

The Accidental Birth of Super Glue: Dr. Harry Coover's WWII Discovery
Dr. Harry Coover was trying to develop clear plastic for gun sights during WWII when he accidentally created cyanoacrylate, an extremely strong adhesive. Initially dismissed, it was later marketed as Super Glue in the 1950s.

The Mystery of Canada's Magical Spotted Lake
Lake Khiluk, the world's most mineralized lake, and one of the most mysterious places on Earth. Each of these spots has a distinct chemical content and is said to cure various diseases.

How Dmitri Mendeleev Developed the periodic table of the elements
1850 Dmitri Mendeleev walked almost a thousand miles to Moscow so he could apply for the University of Moscow. Although he was not accepted, he walked to St. Petersburg where he was accepted, And with that education, he developed the the periodic table of the elements

How did Howard Florey discover penicillin
Penicillin was discovered by Alexander Fleming, but he never attempted to turn it into an antibiotic. It wasn't until ten years later that Howard Florey discovered Fleming's obscure paper and understood the mold's potential. Up to 200 million lives may have been saved as a result of Florey's work.

Why are there 24 hours in a day and 60 minutes in an hour
Ancient Babylonians did math in base 60 instead of base 10. That's why we have 60 seconds in a minute and 360 degrees in a circle.

Woman's memory reset every two hours after traumatic accident
Riley Horner, an Illinois teenager was accidentally kicked in the head. As a result of the injury, her memory resets every two hours, and she wakes up thinking every day is June 11. Riley keeps detailed notes of events happening throughout the day, and sets an alarm on her phone every two hours to remind her to review them. Riley also keeps a calendar in her room to remind her what day it is? As she wakes up every morning confused, thinking it's still June 11.

The World’s First Seismograph: How Ancient China Detected Earthquakes 1,800 Years Ago
Over 1,800 years ago, long before modern technology, the ancient Chinese astronomer and inventor Zhang Heng created the world’s first seismograph in 132 AD. This ingenious bronze device could detect distant earthquakes by releasing small balls from dragons’ mouths into toads’ mouths—each indicating a different compass direction. Its historic detection of an earthquake 400 miles away astonished the imperial court and transformed the way societies understood and responded to seismic events.

Man gave his stem cell fund to a disabled boy
Dan Black, who was paralyzed in a bike accident, spent four years raising 20,000 for a stem cell treatment that could let him walk again. However, after learning about a five-year-old boy with cerebral palsy, he donated the funds for the boy's medical treatment in order to enable him to take his first steps.

How a Headache Cure Experiment Led to the Invention of Dynamite
Alfred Nobel discovered dynamite while experimenting with nitroglycerin, a volatile liquid he also took in tiny doses for headaches. Ironically, the explosive that made him wealthy and feared also eased pain—later inspiring his legacy as founder of the Nobel Prizes.

Dr. Donald Hopkins: From Smallpox Eradication to Near-Ending Guinea Worm Disease
Dr. Donald Hopkins helped eradicate Smallpox, and is on the verge of killing another disease. He's taken Guinea Worm Disease down from 3.5 million cases a year to just 28 cases last year.

Dr. Leonid Rogozov: the surgeon who removed his own appendix.
Dr. Leonid Rogozov was a legendary surgeon who operated on himself in 1961 to remove an inflamed appendix.

Mystery of 300-year-old mummified mermaid is being probed
There is a 300-year-old mummified mermaid with 30 centimetres tall and features a human-like head, two hands with what appear to be fingernails, and its lower body that look like a fish tail. The “mermaid mummy” is being probed by Japanese scientists in an attempt to unravel the mystery of its existence.

The Unique Grana Double Tree of Piedmont, Italy
The “Grana Double Tree” in Piedmont, Italy is a highly unusual tree, which consists of a cherry tree growing atop a mulberry tree. It is essentially a two-species, two-tiered hybrid duplex.

Ocean Atlas: Exploring the World’s Largest Underwater Sculpture in the Bahamas
On the western coast of New Providence in Nassau, Bahamas, there is a tourist attraction that you can dive down to see. Called Ocean Atlas, this is the largest single underwater sculpture ever installed. It depicts a local Bahamian girl carrying the weight of the ocean, in reference to the Ancient Greek myth of Atlas holding up the heavens.

Why Some Animals Can Regenerate Limbs and What Science Says About Human Possibilities
Certain animals possess the extraordinary ability to regenerate lost limbs, a process that has fascinated scientists and inspired hopes for human medical breakthroughs. From salamanders’ perfect limb regrowth to starfish’s incredible body regeneration, this article explores how and why these animals can perform such feats, the biological mechanisms underpinning regeneration, and what cutting-edge research means for the future of human limb regeneration.

The extraordinary case of Olivia Farnsworth, who hit by a car and dragged down the street without pain because of chromosome 6 deletion
In 2016, 7-year-old Olivia Farnsworth was hit by a car and dragged down the street, but she did not feel a thing. That is because of a rare condition called “chromosome 6 deletion,” which causes her to feel no pain. She also does not experience hunger or exhaustion.

How Sleep Cycles Affect Cognitive Function and Memory Retention
Sleep is not just rest—it's an active process where our brain cycles through stages that shape cognition, memory, and overall mental performance. Different sleep phases, from deep slow-wave sleep to REM dreaming, play unique roles in consolidating memories, boosting attention, and refreshing brain networks. Explore how sleep cycles work and why they are essential to learning and sharp thinking.